This article comes from WeChat public account: the power of machines (ID: almosthuman2017) , author: the machine can be, from the title figure: Figure worm

After receiving anti-AIDS and anti-influenza drugs, a Chinese new crown patient with severe illness showed promising results in Thailand-the condition improved significantly within 12 hours, and the test result became negative within 48 hours.

Before, the effectiveness of anti-AIDS drugs in the treatment of new pneumonia has aroused widespread concern in the society. However, the results of the study or the analysis and judgment are all based on the use of anti-AIDS drugs alone, and there have been no reports about the use of anti-influenza drugs.

The case is special because one of the patients was an elderly patient with a new crown and severely ill; the other was that the severely ill patient experienced two sets of treatments and showed different effects: the first hospital used the Thai pharmacy The self-produced anti-AIDS drug did not improve or worsen after 2 days; the second hospital also added oseltamivir, a flu treatment drug, and used a high dose to achieve cure.

It is for this reason that this case is particularly worthy of attention and reference. Although it remains to be seen whether the treatment is up to standard, the results of the cure are already exciting.

At 14 pm local time on February 2, Thailand ’s Deputy Prime Minister and Minister of Public Health, Anatin Chanvilakul (Anutin Chanvirakul) < / span> Organized a press conference to declare that the new state-of-the-art Coronavirus pneumonia, Thailand ’s state-run Rajavich (Rajavithi) The hospital ’s team of experts found rapid And effective treatment regimen.

Anantin said that patients with severe neocoronary pneumonia improved after 48 hours of using the protocol, and the results of the detection of the new coronavirus nucleic acid were negative. The prescription is made by using AIDS drugs produced by government medical organizations and supplemented with drugs for treating influenza.

1 Prescription: Lopinavir + Yanatamivir + Oseltavir

Dr. Kriangsak Attipornwanich, a lung disease specialist at Rajavithi Hospital, and the treating doctor of the patient, said:

“On January 29, the hospital received a 70-year-old Chinese Wuhan patient who is a new patient with severe pneumonia who was transferred from Huaxin Hospital. The woman has a very serious condition, including high fever, difficulty breathing, general weakness, and lungs. Sekisui, etc., also suffers from high blood pressure and heart disease. With the spread of inflammation in the lungs of patients, the virus in the blood is increasing every day, even to the point that it is necessary to use a ventilator to help oxygen. “

So, a team of experts at Rajavithi Hospital used medicines for AIDS produced by government medical organizations, supplemented with medicines for flu.

Twelve hours after the medication, the patient’s symptoms have improved, not only the fever has subsided, but also he can sit up and his fatigue has weakened.

After 48 hours of treatment, the doctor tested the patient’s new coronavirus nucleic acid again and found that it had turned negative.

Dr. Kriangsak said that through initial research on effective treatment options, it was found that critically ill patients used anti-AIDS drugs produced by the Thai pharmacy in the first hospital. After 2 days, the situation did not improve and did not worsen. So I used oseltamivir, a drug for the treatment of influenza, and used high-dose drugs because of severe symptoms.

Previous records show that oseltamivir has a certain effect on the treatment of Middle East Respiratory Syndrome Coronavirus (MERS) Severe patients are treated with both drugs at the same time, and then the patient’s condition is closely monitored.

Dr. Kriangsak said that another 33-year-old Thai patient who was diagnosed after taking the two drugs also recovered rapidly.

“We are very excited about this, but at present we cannot guarantee that this prescription is the best medicine for the treatment of new coronary pneumonia, and we have not found such use in other countries, but we did find it effective clinically, so We will continue to study. “

According to the Bangkok Post, the proportion of the two groups of drugs is,

  • 200 mg of lopinavir, 4 to 800 mg per day;


  • Anatavir 50 mg, 4 to 200 mg per day; two drugs in two.


  • Influenza drug group is 300 mg of oseltamivir (Oseltamivir) per day.



    Lopinavir is a protease inhibitor that binds to the catalytic site of HIV protease and interferes with the assembly process of the virus, so it is used as an antiviral drug.

    Ritonavir is also an HIV protease inhibitor, but low-dose ritonavir can also provide blood concentration of lopinavir by inhibiting liver metabolism. For this reason, lopinavir is often used in combination with low-dose ritonavir to treat HIV infection.

    Oseltamivir is the “magic drug” and preferred drug for the treatment of influenza worldwide. It can inhibit mature influenza virus from detaching from host cells, thereby inhibiting the spread of influenza virus in the human body to play a therapeutic epidemic. The effect of a cold.

    Previously, the effectiveness of anti-AIDS drugs in the treatment of new pneumonia has aroused widespread concern in China, but the research results or analysis and judgment are all treatment options using anti-AIDS drugs alone. use together.

    Thai doctors have stated that the use of three antiviral drugs in combination with reference to “cocktail therapy” can improve the treatment effect. Another doctor said that a similar approach in two other patients caused one patient to show some kind of allergic reaction, while the other showed improvement.

    The so-called cocktail therapy, originally referred to as “high-efficiency antiretroviral therapy” (HAART) , Chinese-American scientist He Dayi He proposed in the year to treat AIDS by using three or more antiviral drugs in combination.

    The application of this therapy can reduce the resistance caused by a single medication, minimize the replication of the virus, and restore part or even all of the damaged immune function, thereby delaying the progression of the disease, prolonging the patient’s life, and improving the quality of life. The therapy uses a combination of protease inhibitors and a variety of antiviral drugs to effectively control AIDS.

    Whether this treatment method meets the standard remains to be verified. But the results of the cure are already exciting enough.

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