Southwest Dakota in the United States is preparing to conduct statewide clinical trials to verify the effectiveness of hydroxychloroquine in the treatment of new coronary pneumonia. There are thousands of planned test subjects.
South Dakota Governor Christie Nome announced the news on TV on the 13th. According to her, “Every South Dakota state resident with new coronavirus can consult their doctor to confirm whether they are eligible to participate in the trial and are suitable for hydroxychloroquine treatment.”
She said that both local and outpatients can choose to participate in the trial. The federal government has given full support so that “the amount of medicine available in the state is sufficient to treat up to 100,000 people.” The trial is divided into two parts: one is to conduct clinical trials on confirmed cases; the other is to conduct randomized clinical trials on medical personnel with high risk of contracting the disease.
US President Donald Trump has publicly publicized the “efficacy” of chloroquine drugs against the new coronavirus. At that time, only a small-scale French clinical trial showed that this kind of resistance The old malaria medicine seems to show a certain effect of curbing the virus. In subsequent trials conducted in different countries, the effectiveness and safety of treatment regimens using chloroquine and other chloroquine compounds have not been fully verified.
The Associated Press reported that a Brazilian scientific research team recently stopped some chloroquine clinical trials because of the arrhythmia of some subjects after injection of drugs. The trial was launched in the Amazon Basin area and originally planned to recruit 440 new patients with critical illness. But after 81 patients received treatment, the researchers published the results of a trial on a research website, showing that one-quarter of those who injected two 600-mg daily doses of chloroquine for 10 consecutive days developed heart rhythm problems, and the trial group died The rate increased; the other group received two doses of 450 mg of chloroquine on the first day and one dose per day for the next four days. The results are unknown. At present, only one patient received pharyngeal swab samples and no virus was found. Since all patients were injected with two antibiotics at the same time, it was impossible to determine whether the side effects originated from chloroquine.
Brazilian President Jayle Bosonaro also repeatedly promoted the “effectiveness” of the combination of chloroquine and antibiotics, canceled the import tariff of chloroquine, and instructed the military laboratory to step up Production of chloroquine.
(original title: the first statewide hydroxychloroquine new crown trial in the United States)