China-Singapore Online News on May 27, the reporter was informed on the 27th that researchers such as Professor Ying Tianlei from the School of Basic Medical Sciences of Fudan University and other researchers have discovered a series of anti-new crown fully human-derived nanobodies to develop new drugs and treatments for new crown virus The plan is of great significance.
It is reported that the results have been published in the latest issue of “Cell” and “Subcellular Hosts and Microorganisms”.
The new coronavirus has infected millions of people worldwide, and there are currently no specific drugs, so there is an urgent need to develop safe and effective antiviral antibodies. Professor Tianlei Lei said that all human sources mean that the genes of antibodies are all derived from humans.
In recent years, a new class of antibodies called “nanoantibodies” has been favored by the pharmaceutical industry due to their small molecular weight, low production cost, and stable properties. However, Nanobodies are derived from camel or alpaca, and even after humanization, they still contain certain camel-derived ingredients, which poses potential safety hazards for human use.
In order to solve the hidden safety problem, Yingtianlei research team and collaborators developed a new technology, which was the first to design a fully human Nanobody with natural germline genes . High affinity, low cost, fast production, and easy purification are the characteristics of this type of fully human Nanobodies.
Due to its small size and excellent physicochemical properties, this class of fully human Nanobodies can be developed as a nebulized inhalation preparation to rapidly deliver large amounts of antibodies to alveolar and other lesions . Ying Tianlei said that in theory, it is especially suitable for the treatment of respiratory diseases such as new coronary pneumonia.
Using this new technology, the research team successfully screened dozens of fully human Nanobodies against the new coronavirus receptor binding region, two of which are potent The fully human Nanobody of the new coronavirus can target the specific hidden epitope of the virus S protein.
(Originally titled “Chinese Scholars Discover Anti-New Crown Full Human Nanobodies, Can Be Developed as New Drugs”)