After entering the 19th century, due to the emergence of ships, trains, and emerging industrial cities, cholera began to rag the world, and it became popular 7 times worldwide, 6 of which were in the 19th century. World Disease. ” In London in 1854, the doctor John Snow fights the cholera epidemic on his own, opening the preface of “epidemiology” and leaving a great revelation for future generations. Cholera is an acute intestinal infectious disease caused by Vibrio cholerae. It has rapid onset, rapid spread, wide spread and serious harm, and is often transmitted by water, food, daily contact and flies. And in an era when no pathogen was known, by what did he stop the spread of cholera? What can we learn from the current fight against the new crown pneumonia epidemic?